Pain Management & Regenerative Medicine
Dr. Rainier Guiang, MD — Inland Empire
Welcome to our regenerative medicine clinic, where we specialize in regenerative medicine that goes beyond temporary solutions. Our dedicated team is committed to restoring your quality of life through innovative treatments tailored to your needs.
From Pain Management to Regenerative Medicine
Founded with a vision to transform pain management, University Pain Consultants has evolved significantly over the years. Starting as a small practice in 2007, we embraced advancements in traditional pain management treatments. Through years of trialing all the “newest” treatments available, we have figured out what works and what doesn’t. We have come to realize there are many innovative and worthwhile treatments that have proven to be effective in many conditions. However many of these modalities are considered “experimental” or “not medically necessary” by most health insurance plans. In this clinic, we offer you many of the treatments we have found to be effective despite what the insurance companies tell you.
Each milestone in our journey reflects our commitment to patient care and education. We aim not only to relieve pain but also to empower our patients with knowledge about their treatment options. Join us as we continue to pave the way for effective and compassionate healing.
Our Mission - Beyond Management
At the Regenerative Medicine Clinic at University Pain Consultants, our mission is to transform the lives of chronic pain patients by moving beyond management and toward genuine healing. Through regenerative procedures such as platelet-rich plasma (PRP) and red light therapy, we work with the body’s own natural healing mechanisms to restore function and repair tissue at the cellular level. Combined with evidence-based nutritional interventions and IV ketamine infusion therapy — which harnesses the brain’s neuroplasticity to break entrenched pain cycles — we address the root causes of pain, not merely its symptoms.
We believe chronic pain is not a life sentence. Every patient deserves the opportunity to heal, regain function, and reclaim their quality of life. We are redefining what is possible for those who have been told that management is their only option.
About Dr. Rainier Guiang, MD
Dr. Rainier Guiang, MD is a board-certified pain management specialist and the director of the Regenerative Medicine program at University Pain Consultants. He holds dual board certifications from the American Board of Anesthesiology in both Anesthesiology and Pain Medicine. His clinical focus is on regenerative and integrative approaches to chronic pain — specifically platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) therapy, IV ketamine infusions, and low dose naltrexone (LDN) — for patients who have not found adequate relief through conventional treatments.
Training and credentials
Dr. Guiang is a California native who earned his Bachelor of Science in Biological Sciences from the University of California, Los Angeles in 1995. He earned his medical degree from the American University of the Caribbean School of Medicine in 1999, followed by an internal medicine residency at Creighton University School of Medicine / Maricopa Medical Center in Phoenix. Recognizing that the most intractable clinical problems he encountered were in chronic pain, he transitioned to anesthesiology, completing his residency and then his Pain Medicine fellowship at Case Western Reserve University / University Hospitals Cleveland Medical Center — one of the country’s leading academic pain programs. He became board certified in Anesthesiology in 2004 and in Pain Medicine in 2005 through the American Board of Anesthesiology.
He has contributed to the training of medical students and residents throughout his career. He co-founded University Pain Consultants in 2007 and has grown the practice to six locations across the Inland Empire, including Riverside, Corona, Temecula, Menifee, Hemet, and San Bernardino.
Why regenerative medicine
Dr. Guiang’s shift toward regenerative medicine was driven by the evidence. After nearly two decades of interventional pain practice, he identified a consistent pattern: many patients with osteoarthritis, fibromyalgia, complex regional pain syndrome, and central sensitization syndromes were cycling through treatments — injections, medications, procedures — that addressed symptoms without altering the underlying biology. The clinical literature on PRP, IV ketamine, and LDN offered something different: mechanisms that could interrupt or reverse the pathological processes driving chronic pain, not merely suppress them.
For PRP and PRF therapy, the evidence base in osteoarthritis and tendinopathy showed durable outcomes that cortisone could not match, without the tissue-degrading effects of repeated steroid exposure. For IV ketamine, the NMDA antagonist mechanism offered a direct intervention on central sensitization — the neurological wind-up that makes chronic pain self-perpetuating — with response rates in CRPS and fibromyalgia that exceeded conventional pharmacology. For low dose naltrexone, Stanford-led placebo-controlled trials in fibromyalgia demonstrated that modulating microglial activity could meaningfully reduce pain burden in a population that had largely been told management was their only option.
These are evidence-supported approaches that the mainstream insurance and reimbursement system has been slow to adopt — which means they are available only in practices willing to operate outside that system and be transparent with patients about cost and evidence. That is the model at University Pain Consultants Regenerative Medicine.
Clinical philosophy
Dr. Guiang approaches chronic pain as a systemic, neurobiological problem that requires individualized solutions. His goal for every patient is to identify the specific mechanisms driving their pain — whether peripheral tissue injury, central sensitization, neuroinflammation, or some combination — and apply the most targeted intervention available. He is equally committed to minimizing long-term opioid dependence and to offering patients honest, evidence-grounded answers about what is likely to help and what is not.
Patients come to the University Pain Consultants Regenerative Medicine program from across the Inland Empire and Southern California, often after years of inadequate relief from conventional pain management. Dr. Guiang and his team evaluate each patient with the goal of finding a better answer.
Credentials
- BS, Biological Sciences — University of California, Los Angeles, 1995
- MD, American University of the Caribbean School of Medicine, 1999
- Residency, Internal Medicine — Creighton University / Maricopa Medical Center, Phoenix, 1999–2001
- Residency, Anesthesiology — Case Western Reserve University / University Hospitals Cleveland, 2001–2004
- Fellowship, Pain Medicine — Case Western Reserve University / University Hospitals Cleveland, 2004–2005
- Board Certified, Anesthesiology — American Board of Anesthesiology, 2004
- Board Certified, Pain Medicine — American Board of Anesthesiology, 2005
- Co-founder, University Pain Consultants, 2007–present
- Director, Regenerative Medicine Program, University Pain Consultants
- CA Medical License, active
